Australian coach Tim Sheens is considering using Brent Tate from the interchange bench and playing Michael Jennings on the wing as part of a revamp forced by the loss of star fullback Billy Slater.
The possible selection shocks for next weekend's World Cup semi-final indicate that Canterbury's Josh Morris will be chosen at left centre to cover for Slater, with Greg Inglis moving to fullback.
But the other two centres not used in Saturday's 62-0 quarter final defeat of USA may also play at Wembley after the injury to Slater underlined how much the Kangaroos miss Luke Lewis, who returned home last week to undergo a shoulder reconstruction.
If Lewis had been in the squad, he would have moved to centre but in his absence Sheens was was forced to play Daly Cherry-Evans and Greg Bird at left centre after losing Slater with a knee injury in the 42nd minute.
Boyd Cordner is the only forward in the depleted squad who can cover for an injury in the centres if needed but, as with Cherry-Evans and Bird, there would be concerns about how well he would do against New Zealand or England if required to play there for a long period.
An alternative being weighed up by Sheens is to pick a centre on the bench who can play in the back row and Tate is considered to be better suited to that role than Jennings, Morris or Jarryd Hayne, who sealed the right-centre berth with his four-try effort against the Tomahawks.
Right winger Brett Morris also equalled the World Cup record of four tries in a match but left winger Darius Boyd had little involvement in the match, touching the ball just three times in each half and he was the only Australian back not to make a line break or tackle break in the match.
As a result, Sheens may give Jennings a chance on the wing next weekend as the Sydney Roosters and NSW centre is a great finished and easily the fastest player in the Kangaroos squad.
Such a move would be considered radical as Boyd has been a mainstay of the Australian team since 2008 and he has scored 11 tries in 13 Tests, as well as 12 tries in 17 Origin appearances.
However, almost all of Boyd's tries for the Kangaroos and Queensland were scored playing outside Inglis and Sheens made it clear when he selected Inglis at fullback against Fiji two weeks ago that the South Sydney superstar was the next choice No. 1 after Slater.
With Slater out of the World Cup semi-final, Sheens will move Inglis to fullback and may also blood a new look right side combination in Josh Morris and Jennings.
"If we do lose Billy obviously GI will move to fullback at this point so one of the three centres who didn't play [against the Tomahakws] will be quite happy to jump into that spot," Sheens said at the post-match press conference.
"It is another challenge because I have got three quality players there [Morris, Jennings and Tate]."
However, Sheens admitted he was concerned about the Kangaroos lack of cover on the bench for an injury to one of the outside backs.
"We didn't carry an outside back and that probably exposed us a bit for a minute. Cherry was there for a moment but [Clint] Newton saw Cherry and Johnathan [Thurston] standing side by side . . . so we swapped a few people around and moved him [Cherry-Evans] in a bit tighter.
"I had wanted to experiment with him at No. 9 so that enabled us to do that but then we ended up with Greg Bird in the centres which isn't going to happen next week, that's for sure.
"It exposed us and was probably a good chance for us to remember that going forward because we don't have Luke Lewis."
Cherry-Evans was included as the bench utility ahead of back-up hooker Robbie Farah following a man of the match performance in last week's 50-0 defeat of Ireland and Sheens is expected to stick with him in that role.